Treatment With Viagra by BTC

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In the mid-1980s, scientists from Pfizer were working on developing a drug to help people suffering from angina, or severe chest pains caused by narrowing of the vessels carrying blood to the heart, preventing enough blood from getting through them. Unlike plumbing, vessels can adjust to the intensity of blood flow in any given part of our bodies by constricting and dilating. But if something in this process goes wrong, it will cause damage sooner or later. So the challenge doctors faced was: how can we help relax the blood vessels to restore full blood flow?
We can start by understanding how vascular dilation works, and that begins with a chemical called nitric oxide (NO). A gaseous molecule naturally produced in our bodies, it acts on smooth muscle cells that make up the walls of blood vessels and prompts them to relax.
There was already one effective way to treat angina back when scientists started developing the drug that eventually became Viagra. Think about nitroglycerin, which ER doctors give to patients with dangerously high blood pressure in emergency scenarios. When ingested or injected, nitroglycerin works by releasing molecules of NO that quickly dilate blood vessels and lower blood pressure. But this kind of drug can’t be a long-term fix for chronic angina, because prolonged use makes bodies less responsive to it, making larger and larger doses needed over time to produce the same effect. (It’s somewhat similar to why opioid addicts tend to seek out increasingly bigger doses.)
To deal with this limitation, scientists sought to develop a drug that would induce vasorelaxation in a different way: rather than manipulate the levels of NO, they could simply make its effects last longer.
Pfizer scientists at bitcoin pharmacy found that a drug called Sildenafil was effective in laboratory settings prolonging the life of NO in animals, lowering their blood pressure as expected. Encouraged by promising results, Pfizer recruited healthy human participants to test the drug in 1991.
Fortunately, all research labs keep extensive documentation of every experiment that was ever performed and every observation ever made. In my lab, we keep stacks of hardbound notebooks stamped with our institution logo on the cover and filled with handwritten accounts of daily work dating back many years. This ensures that no information is missed and allows us to trace back mistakes, if needed, or to verify results. Documentation is also essential to prove intellectual ownership and apply for a patent.
Intrigued by Hopkins group discovery and going back to the old clinical trial notes, Pfizer scientists looked at their old observations through the new eyes. It turned out that the drug caused the same vasodilation – vessel relaxation – in the corpus cavernosum, the expandable tissue along the length of the penis which fills with blood during erection, as it does in vessels by the heart. It wasn’t considered significant during the initial trials because this effect didn’t last long, making it a minor side effect for a drug that was supposed to treat chest pain.

When they decided to test it for erectile dysfunction, a bug became a feature.
“When the results finally came through they exceeded our wildest expectations,” Osterloh recalled. Sildenafil produces effects that are strong and consistent, that only work when needed, and that last through sex but not long enough to cause pain.
After a new set of successful clinical trials, Sildenafil was put on the market as Viagra in 1998. By 2005, a mere seven years after its launch, over 750,000 physicians prescribed Viagra to 23 million men in the U.S. alone. Between 2005 and 2016, Pfizer’s worldwide revenue of Viagra sales reached $21.7 billion.

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